Matches in UGent Biblio for { <https://biblio.ugent.be/publication/3163020#aggregation> ?p ?o. }
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- aggregation classification "A2".
- aggregation creator B512299.
- aggregation creator B512300.
- aggregation creator B512301.
- aggregation creator B512302.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 3163020.bibtex.
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- aggregation hasFormat 3163020.didl.
- aggregation hasFormat 3163020.doc.
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- aggregation hasFormat 3163020.txt.
- aggregation hasFormat 3163020.xls.
- aggregation hasFormat 3163020.yaml.
- aggregation isPartOf urn:issn:2163-9450.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Alteration of liver N-glycome in patients with hepatocellular carcinoma".
- aggregation abstract "Purpose: Alteration of liver function during progression of hepatocellular carcinoma (HCC) and cirrhosis affects the serum glycoprotein pattern. In this study, the changes in the N-glycome in liver tissue from patients with hepatocellular carcinoma and cirrhosis caused by hepatitis B virus infection were investigated to find out the relationship between this maker and liver disease. Methods: Twenty patients, 11 with cirrhosis and 9 with hepatocellular carcinoma, and 15 healthy donors were involved in this study. Liver protein N-glycans were profiled using the DSA-FACE technique developed in our laboratory. To further analyze the fucosylation status of these liver glycans Western lectin blots of total liver proteins were performed using Aspergillus oryzae lectin (AOL) as probe, which is a carbohydrate-binding protein that recognizes specifically α-1,6-fucosylated glycans. Results: The N-glycome of liver proteins in patients with HBV related HCC and cirrhosis was analyzed. Compared with healthy donors, the N-glycome had significantly less (p < 0.05) high mannose (M8) in both groups of patients. The total core α-1,6-fucosylation in total liver glycopro-teins was dramatically increased during the progress of hepatocellular carcinoma and cirrhosis compared to the controls. Conclusion: These results show that fucosylation not only increases in serum proteins but also in liver tissue itself of patients with HBV related HCC and cirrhosis.".
- aggregation authorList BK859185.
- aggregation endPage "8".
- aggregation issue "1".
- aggregation startPage "1".
- aggregation volume "2".
- aggregation aggregates 3163103.
- aggregation isDescribedBy 3163020.
- aggregation similarTo ojgas.2012.21001.
- aggregation similarTo LU-3163020.