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- aggregation classification "A1".
- aggregation creator B471264.
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- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 3171566.bibtex.
- aggregation hasFormat 3171566.csv.
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- aggregation isPartOf urn:issn:1061-4036.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression".
- aggregation abstract "LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7 family. A role for LIN28B in cancer has been proposed but has not been established in vivo. Here, we report that LIN28B showed genomic aberrations and extensive overexpression in high-risk neuroblastoma compared to several other tumor entities and normal tissues. High LIN28B expression was an independent risk factor for adverse outcome in neuroblastoma. LIN28B signaled through repression of the let-7 miRNAs and consequently resulted in elevated MYCN protein expression in neuroblastoma cells. LIN28B-let-7-MYCN signaling blocked differentiation of normal neuroblasts and neuroblastoma cells. These findings were fully recapitulated in a mouse model in which LIN28B expression in the sympathetic adrenergic lineage induced development of neuroblastomas marked by low let-7 miRNA levels and high MYCN protein expression. Interference with this pathway might offer therapeutic perspectives.".
- aggregation authorList BK809853.
- aggregation endPage "1206".
- aggregation issue "11".
- aggregation startPage "1199".
- aggregation volume "44".
- aggregation aggregates 3171801.
- aggregation isDescribedBy 3171566.
- aggregation similarTo ng.2436.
- aggregation similarTo LU-3171566.