Matches in UGent Biblio for { <https://biblio.ugent.be/publication/3182275#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B608034.
- aggregation creator B608035.
- aggregation creator B608036.
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- aggregation date "2013".
- aggregation format "application/pdf".
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- aggregation isPartOf urn:issn:0022-1767.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination".
- aggregation abstract "The paracaspase MALT 1 is a major player in lymphocyte activation and proliferation. MALT1 mediates Ag-induced signaling to the transcription factor NF-kappa B by functioning both as a scaffold protein and cysteine protease. We studied the role of MALT1 in the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. MALT1-knockout mice did not develop any clinical symptoms of EAE. In addition, lymphocyte and macrophage infiltration into the spinal cord was absent in MALT1-knockout mice, as were demyelination and proinflammatory gene expression. Adoptive transfer experiments showed that MALT1 deficiency in splenocytes is sufficient for EAE resistance. Moreover, autoreactive T cell activation was severely impaired in MALT1-deficient T cells, suggesting the inability of MALT1-deficient effector T cells to induce demyelinating inflammation in the CNS. Finally, the MALT1 substrates A20 and CYLD were completely processed in wild-type T cells during EAE, which was partially impaired in MALT1-deficient T cells, suggesting a contribution of MALT1 proteolytic activity in T cell activation and EAE development. Together, our data indicate that MALT1 may be an interesting therapeutic target in the treatment of multiple sclerosis.".
- aggregation authorList BK966707.
- aggregation endPage "2903".
- aggregation issue "6".
- aggregation startPage "2896".
- aggregation volume "190".
- aggregation aggregates 4381121.
- aggregation isDescribedBy 3182275.
- aggregation similarTo jimmunol.1201351.
- aggregation similarTo LU-3182275.