Matches in UGent Biblio for { <https://biblio.ugent.be/publication/3186890#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B460487.
- aggregation creator B460488.
- aggregation creator B460489.
- aggregation creator B460490.
- aggregation creator B460491.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 3186890.bibtex.
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- aggregation hasFormat 3186890.didl.
- aggregation hasFormat 3186890.doc.
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- aggregation isPartOf urn:issn:1742-206X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Inferring the transcriptional network of Bacillus subtilis".
- aggregation abstract "The adaptation of bacteria to the vigorous environmental changes they undergo is crucial to their survival. They achieve this adaptation partly via intricate regulation of the transcription of their genes. In this study, we infer the transcriptional network of the Gram-positive model organism, Bacillus subtilis. We use a data integration workflow, exploiting both motif and expression data, towards the generation of condition-dependent transcriptional modules. In building the motif data, we rely on both known and predicted information. Known motifs were derived from DBTBS, while predicted motifs were generated by a de novo motif detection method that utilizes comparative genomics. The expression data consists of a compendium of microarrays across different platforms. Our results indicate that a considerable part of the B. subtilis network is yet undiscovered; we could predict 417 new regulatory interactions for known regulators and 453 interactions for yet uncharacterized regulators. The regulators in our network showed a preference for regulating modules in certain environmental conditions. Also, substantial condition-dependent intra-operonic regulation seems to take place. Global regulators seem to require functional flexibility to attain their roles by acting as both activators and repressors.".
- aggregation authorList BK798572.
- aggregation endPage "1852".
- aggregation issue "12".
- aggregation startPage "1840".
- aggregation volume "5".
- aggregation aggregates 3189716.
- aggregation isDescribedBy 3186890.
- aggregation similarTo b907310h.
- aggregation similarTo LU-3186890.