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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 3196408.bibtex.
- aggregation hasFormat 3196408.csv.
- aggregation hasFormat 3196408.dc.
- aggregation hasFormat 3196408.didl.
- aggregation hasFormat 3196408.doc.
- aggregation hasFormat 3196408.json.
- aggregation hasFormat 3196408.mets.
- aggregation hasFormat 3196408.mods.
- aggregation hasFormat 3196408.rdf.
- aggregation hasFormat 3196408.ris.
- aggregation hasFormat 3196408.txt.
- aggregation hasFormat 3196408.xls.
- aggregation hasFormat 3196408.yaml.
- aggregation isPartOf urn:issn:1935-2735.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Biology and Life Sciences".
- aggregation title "A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae".
- aggregation abstract "The aim of this study was to explore the mechanisms of resistance against invading Ascaris suum larvae in pigs. Pigs received a low dose of 100 A. suum eggs daily for 14 weeks. This resulted in a .99% reduction in the number of larvae that could migrate through the host after a challenge infection of 5000 A. suum eggs, compared to naı¨ve pigs. Histological analysis at the site of parasite entry, i.e. the caecum, identified eosinophilia, mastocytosis and goblet cell hyperplasia. Increased local transcription levels of genes for IL5, IL13, eosinophil peroxidase and eotaxin further supported the observed eosinophil influx. Further analysis showed that eosinophils degranulated in vitro in response to contact with infective Ascaris larvae in the presence of serum from both immune and naı¨ve animals. This effect was diminished with heat-inactivated serum, indicating a complement dependent mechanism. Furthermore, eosinophils were efficient in killing the larvae in vitro when incubated together with serum from immune animals, suggesting that A. suum specific antibodies are required for efficient elimination of the larvae. Together, these results indicate an important role for eosinophils in the intestinal defense against invading A. suum larvae.".
- aggregation authorList BK1036177.
- aggregation issue "3".
- aggregation volume "7".
- aggregation aggregates 3196454.
- aggregation isDescribedBy 3196408.
- aggregation similarTo journal.pntd.0002138.
- aggregation similarTo LU-3196408.