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- aggregation classification "A1".
- aggregation creator B605389.
- aggregation creator B605390.
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- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 3213057.bibtex.
- aggregation hasFormat 3213057.csv.
- aggregation hasFormat 3213057.dc.
- aggregation hasFormat 3213057.didl.
- aggregation hasFormat 3213057.doc.
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- aggregation hasFormat 3213057.txt.
- aggregation hasFormat 3213057.xls.
- aggregation hasFormat 3213057.yaml.
- aggregation isPartOf urn:issn:0950-9232.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells".
- aggregation abstract "Neuroblastonna is an embryonal tumor with a heterogeneous clinical course. The tumor is presumed to be derived from the neural crest, but the cells of origin remain to be determined. To date, few recurrent genetic changes contributing to neuroblastoma formation, such as amplification of the MYCN oncogene and activating mutations of the ALK oncogene, have been identified. The possibility to model neuroblastoma in mice allows investigation of the cell of origin hypothesis in further detail. Here we present the evidence that murine neural crest progenitor cells can give rise to neuroblastonna upon transformation with MYCN or ALK(F1174L). For this purpose we used JoMa1, a multipotent neural crest progenitor cell line, which is kept in a viable and undifferentiated state by a tamoxifen-activated c-Myc transgene (c-MycER(T)). Expression of MYCN or ALK(F1174L), one of the oncogenic ALK variants identified in primary neuroblastomas, enabled these cells to grow independently of c-MycER(T) activity in vitro and caused formation of neuroblastoma-like tumors in vivo in contrast to parental JoMa1 cells and JoMa1 cells-expressing TrkA or GFP. Tumorigenicity was enhanced upon serial transplantation of tumor-derived cells, and tumor cells remained susceptible to the MYC-inhibitor, NBT-272, indicating that cell growth depended on functional MYCN. Our findings support neural crest progenitor cells as the precursor cells of neuroblastoma, and indicate that neuroblastomas arise as their malignant progeny.".
- aggregation authorList BK961204.
- aggregation endPage "1065".
- aggregation issue "8".
- aggregation startPage "1059".
- aggregation volume "32".
- aggregation aggregates 3213119.
- aggregation isDescribedBy 3213057.
- aggregation similarTo onc.2012.106.
- aggregation similarTo LU-3213057.