Matches in UGent Biblio for { <https://biblio.ugent.be/publication/3214560#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator person.
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- aggregation date "2013".
- aggregation format "application/pdf".
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- aggregation isPartOf urn:issn:1933-0219.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Natural and long-lasting cellular immune responses against influenza in the M2e-immune host".
- aggregation abstract "Influenza is a global health concern. Licensed influenza vaccines induce strain-specific virus-neutralizing antibodies but hamper the induction of possibly cross-protective T-cell responses upon subsequent infection. (1) In this study, we compared protection induced by a vaccine based on the conserved extracellular domain of matrix 2 protein (M2e) with that of a conventional whole inactivated virus (WIV) vaccine using single as well as consecutive homo-and heterosubtypic challenges. Both vaccines protected against a primary homologous (with respect to hemagglutinin and neuraminidase in WIV) challenge. Functional T-cell responses were induced after primary challenge of M2e-immune mice but were absent in WIV-vaccinated mice. M2e-immune mice displayed limited inducible bronchus-associated lymphoid tissue, which was absent in WIV-immune animals. Importantly, M2e-but not WIV-immune mice were protected from a primary as well as a secondary, severe heterosubtypic challenge, including challenge with pandemic H1N1 2009 virus. Our findings advocate the use of infection-permissive influenza vaccines, such as those based on M2e, in immunologically naive individuals. The combined immune response induced by M2e-vaccine and by clinically controlled influenza virus replication results in strong and broad protection against pandemic influenza. We conclude that the challenge of the M2e-immune host induces strong and broadly reactive immunity against influenza virus infection.".
- aggregation authorList BK959862.
- aggregation endPage "287".
- aggregation issue "2".
- aggregation startPage "276".
- aggregation volume "6".
- aggregation aggregates 3214997.
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- aggregation similarTo mi.2012.69.
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