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- aggregation classification "A1".
- aggregation creator B603802.
- aggregation creator B603803.
- aggregation creator B603804.
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- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 3222399.bibtex.
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- aggregation isPartOf urn:issn:0891-6640.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Plasma ACTH precursors in cats with pituitary-dependent hyperadrenocorticism".
- aggregation abstract "Background : Diagnosis of pituitary-dependent hyperadrenocorticism (PDH) in cats is challenging because there is no specific diagnostic test. Hypothesis/Objective : The determination of plasma ACTH precursor (POMC and pro-ACTH) concentration might facilitate the diagnosis of PDH in cats. The aim of the study was to evaluate prospectively the plasma concentrations of ACTH precursors in a small cohort of cats with PDH and to estimate the value of this approach for diagnosis. Animals Four groups of cats were included: group 1 (cats with PDH), group 2 (cats with diabetes mellitus but not hyperadrenocorticism (HAC)), group 3 (cats with diabetes mellitus and confirmed acromegaly but not HAC), and group 4 (healthy cats). Methods : PDH diagnosis was based on clinical data, low-dose dexamethasone suppression test (LDDST), and adrenal and pituitary gland computed tomography (CT) scan. For groups 2, 3, and 4, hyperadrenocorticism was excluded by LDDST or urine cortisol:creatinine ratio (UCCR). An immunoluminometric assay was used to determine plasma concentrations of ACTH precursors in the 4 groups of cats. Results : Group 1 contained 9 cats (enlarged pituitary gland in 7/9). Plasma ACTH precursor concentrations ranged from <53 to >1010 similar to pmol/L with 8/9 concentrations =229 similar to pmol/L. Groups 2, 3, and 4 included 13, 7, and 13 cats, respectively. Plasma ACTH precursor concentrations ranged from <53 to 96 similar to pmol/L in group 2, <53 to 72 similar to pmol/L in group 3, and <53 to 99 similar to pmol/L in group 4. Conclusion and Clinical Importance : High plasma concentration of ACTH precursors in cats (>100 similar to pmol/L) is highly suggestive of PDH.".
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- aggregation endPage "581".
- aggregation issue "3".
- aggregation startPage "575".
- aggregation volume "26".
- aggregation aggregates 3222416.
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- aggregation similarTo j.1939-1676.2012.00924.x.
- aggregation similarTo LU-3222399.