Matches in UGent Biblio for { <https://biblio.ugent.be/publication/364535#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B175780.
- aggregation creator B175781.
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- aggregation creator person.
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- aggregation date "2006".
- aggregation format "application/pdf".
- aggregation hasFormat 364535.bibtex.
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- aggregation isPartOf urn:issn:1527-6465.
- aggregation language "eng".
- aggregation publisher "JOHN WILEY & SONS INC".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Early immunosuppression withdrawal after living donor liver transplantation and donor stem cell infusion".
- aggregation abstract "Long-term results of organ transplantation are still limited by serious side effects of immunosuppressive drugs. A major issue, therefore, is to elaborate novel therapeutic protocols allowing withdrawal or minimization of immunosuppressive therapy after transplantation. We report on 3 patients prospectively enrolled in an original protocol designed to promote graft acceptance in living donor liver transplantation, using posttransplant conditioning with high doses of antithymocyte globulin followed by injection of donor-derived stem cells. In 2 patients, early immunosuppression withdrawal was possible, without subsequent graft deterioration. In these 2 cases, in vitro studies showed indices of immunological tolerance as assessed by specific hyporesponsiveness to donor alloantigens in mixed lymphocytes culture. In the third patient, acute rejection rapidly occurred after discontinuation of immunosuppression, and minimal immunosuppression has to be maintained during long-term follow-up. In this case, a clearly distinct immunoreactive profile was observed as compared to tolerant patients, as no specific modulation of the antidonor response was observed in vitro. Of note, no macrochimerism could be detected in any of the 3 patients during the follow-up. In conclusion, these clinical observations demonstrated that, despite the absence of macrochimerism, donor stem cells infusion combined with recipient conditioning may allow early immunosuppression withdrawal or minimization after liver transplantation.".
- aggregation authorList BK430250.
- aggregation endPage "1528".
- aggregation issue "10".
- aggregation startPage "1523".
- aggregation volume "12".
- aggregation aggregates 838636.
- aggregation isDescribedBy 364535.
- aggregation similarTo lt.20872.
- aggregation similarTo LU-364535.