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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2008".
- aggregation format "application/pdf".
- aggregation hasFormat 394329.bibtex.
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- aggregation isPartOf urn:issn:1350-9047.
- aggregation language "eng".
- aggregation publisher "NATURE PUBLISHING GROUP".
- aggregation subject "Science General".
- aggregation title "The mitochondrial serine protease HtrA2/Omi: an overview".
- aggregation abstract "The HtrA family refers to a group of related oligomeric serine proteases that combine a trypsin-like protease domain with at least one PDZ interaction domain. Mammals encode four HtrA proteases, named HtrA1-4. The protease activity of the HtrA member HtrA2/Omi is required for mitochondrial homeostasis in mice and humans and inactivating mutations associated with neurodegenerative disorders such as Parkinson's disease. Moreover, HtrA2/Omi is released in the cytosol, where it contributes to apoptosis through both caspase-dependent and -independent pathways. Here, we review the current knowledge of HtrA2/Omi biology and discuss the signaling pathways that underlie its mitochondrial and apoptotic functions from an evolutionary perspective.".
- aggregation authorList BK629512.
- aggregation endPage "460".
- aggregation issue "3".
- aggregation startPage "453".
- aggregation volume "15".
- aggregation aggregates 2936087.
- aggregation isDescribedBy 394329.
- aggregation similarTo sj.cdd.4402291.
- aggregation similarTo LU-394329.