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- aggregation classification "A1".
- aggregation creator B184165.
- aggregation creator B184166.
- aggregation creator B184167.
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- aggregation date "2008".
- aggregation format "application/pdf".
- aggregation hasFormat 408338.bibtex.
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- aggregation isPartOf urn:issn:0021-9258.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "A temperature-sensitive mutation in the Arabidopsis thaliana phosphomannomutase gene disrupts protein glycosylation and triggers cell death".
- aggregation abstract "Eukaryotic phosphomannomutases (PMMs) catalyze the interconversion of mannose 6-phosphate to mannose 1-phosphate and are essential to the biosynthesis of GDP-mannose. As such, plant PMMs are involved in ascorbic acid (AsA) biosynthesis and N-glycosylation. We report on the conditional phenotype of the temperature-sensitive Arabidopsis thaliana pmm- 12 mutant. Mutant seedlings were phenotypically similar to wild type seedlings when grown at 16 - 18 degrees C but died within several days after transfer to 28 degrees C. This phenotype was observed throughout both vegetative and reproductive development. Protein extracts derived from pmm-12 plants had lower PMM protein and enzyme activity levels. In vitro biochemical analysis of recombinant proteins showed that the mutant PMM protein was compromised in its catalytic efficiency (K-cat/K-m). Despite significantly decreased AsA levels in pmm-12 plants, AsA deficiency could not account for the observed phenotype. Since, at restrictive temperature, total glycoprotein patterns were altered and glycosylation of protein-disulfide isomerase was perturbed, we propose that a deficiency in protein glycosylation is responsible for the observed cell death phenotype.".
- aggregation authorList BK441002.
- aggregation endPage "5718".
- aggregation issue "9".
- aggregation startPage "5708".
- aggregation volume "283".
- aggregation aggregates 3065475.
- aggregation isDescribedBy 408338.
- aggregation similarTo jbc.M704991200.
- aggregation similarTo LU-408338.