Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4106356#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B761090.
- aggregation creator B761091.
- aggregation creator B761092.
- aggregation creator B761093.
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- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4106356.bibtex.
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- aggregation hasFormat 4106356.yaml.
- aggregation isPartOf urn:issn:0022-1007.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength".
- aggregation abstract "In humans, high Notch activation promotes gamma delta T cell development, whereas lower levels promote alpha beta-lineage differentiation. How these different Notch signals are generated has remained unclear. We show that differential Notch receptor-ligand interactions mediate this process. Whereas Delta-like 4 supports both TCR-alpha beta and -gamma delta development, Jagged1 induces mainly alpha beta-lineage differentiation. In contrast, Jagged2-mediated Notch activation primarily results in gamma delta T cell development and represses alpha beta-lineage differentiation by inhibiting TCR-beta formation. Consistently, TCR-alpha beta T cell development is rescued through transduction of a TCR-beta transgene. Jagged2 induces the strongest Notch signal through interactions with both Notch1 and Notch3, whereas Delta-like 4 primarily binds Notch1. In agreement, Notch3 is a stronger Notch activator and only supports gamma delta T cell development, whereas Notch1 is a weaker activator supporting both TCR-alpha beta and -gamma delta development. Fetal thymus organ cultures in JAG2-deficient thymic lobes or with Notch3-blocking antibodies confirm the importance of Jagged2/Notch3 signaling in human TCR-gamma delta differentiation. Our findings reveal that differential Notch receptor-ligand interactions mediate human TCR-alpha beta and -gamma delta T cell differentiation and provide a mechanistic insight into the high Notch dependency of human gamma delta T cell development.".
- aggregation authorList BK1128263.
- aggregation endPage "697".
- aggregation issue "4".
- aggregation startPage "683".
- aggregation volume "210".
- aggregation aggregates 4206084.
- aggregation isDescribedBy 4106356.
- aggregation similarTo jem.20121798.
- aggregation similarTo LU-4106356.