Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4110313#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B838333.
- aggregation creator B838334.
- aggregation creator B838335.
- aggregation creator B838336.
- aggregation creator B838337.
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- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4110313.bibtex.
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- aggregation isPartOf urn:issn:0028-646X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Ectopic expression of Kip-related proteins restrains root-knot nematode-feeding site expansion".
- aggregation abstract "The development of nematode feeding sites induced by root-knot nematodes involves the synchronized activation of cell cycle processes such as acytokinetic mitoses and DNA amplification. A number of key cell cycle genes are reported to be critical for nematode feeding site development. However, it remains unknown whether plant cyclin-dependent kinase (CDK) inhibitors such as the Arabidopsis interactor/inhibitor of CDK (ICK)/Kip-related protein (KRP) family are involved in nematode feeding site development. This study demonstrates the involvement of Arabidopsis ICK2/KRP2 and ICK1/KRP1 in the control of mitosis to endoreduplication in galls induced by the root-knot nematode Meloidogyne incognita. Using ICK/KRP promoter-GUS fusions and mRNA in situ hybridizations, we showed that ICK2/KRP2, ICK3/KRP5 and ICK4/KRP6 are expressed in galls after nematode infection. Loss-of-function mutants have minor effects on gall development and nematode reproduction. Conversely, overexpression of both ICK1/KRP1 and ICK2/KRP2 impaired mitosis in giant cells and blocked neighboring cell proliferation, resulting in a drastic reduction of gall size. Studying the dynamics of protein expression demonstrated that protein levels of ICK2/KRP2 are tightly regulated during giant cell development and reliant on the presence of the nematode. This work demonstrates that impeding cell cycle progression by means of ICK1/KRP1 and ICK2/KRP2 overexpression severely restricts gall development, leading to a marked limitation of root-knot nematode development and reduced numbers of offspring.".
- aggregation authorList BK1213320.
- aggregation endPage "519".
- aggregation issue "2".
- aggregation startPage "505".
- aggregation volume "199".
- aggregation aggregates 4110326.
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