Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4118026#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B838297.
- aggregation creator B838298.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4118026.bibtex.
- aggregation hasFormat 4118026.csv.
- aggregation hasFormat 4118026.dc.
- aggregation hasFormat 4118026.didl.
- aggregation hasFormat 4118026.doc.
- aggregation hasFormat 4118026.json.
- aggregation hasFormat 4118026.mets.
- aggregation hasFormat 4118026.mods.
- aggregation hasFormat 4118026.rdf.
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- aggregation hasFormat 4118026.txt.
- aggregation hasFormat 4118026.xls.
- aggregation hasFormat 4118026.yaml.
- aggregation isPartOf urn:issn:2211-1247.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "The ROSA26-iPSC mouse: a conditional, inducible, and exchangeable resource for studying cellular (de)differentiation".
- aggregation abstract "Control of cellular (de)differentiation in a temporal, cell-specific, and exchangeable manner is of paramount importance in the field of reprogramming. Here, we have generated and characterized a mouse strain that allows iPSC generation through the Cre/loxP conditional and doxycycline/rtTA-controlled inducible expression of the OSKM reprogramming factors entirely from within the ROSA26 locus. After reprogramming, these factors can be replaced by genes of interest-for example, to enhance lineage-directed differentiation-with the use of a trap-coupled RMCE reaction. We show that, similar to ESCs, Dox-controlled expression of the cardiac transcriptional regulator Mesp1 together with Wnt inhibition enhances the generation of functional cardiomyocytes upon in vitro differentiation of such RMCE-retargeted iPSCs. This ROSA26-iPSC mouse model is therefore an excellent tool for studying both cellular reprogramming and lineage-directed differentiation factors from the same locus and will greatly facilitate the identification and ease of functional characterization of the genetic/epigenetic determinants involved in these complex processes.".
- aggregation authorList BK1213239.
- aggregation endPage "341".
- aggregation issue "2".
- aggregation startPage "335".
- aggregation volume "3".
- aggregation aggregates 4118983.
- aggregation isDescribedBy 4118026.
- aggregation similarTo j.celrep.2013.01.016.
- aggregation similarTo LU-4118026.