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- aggregation classification "A1".
- aggregation creator person.
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- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4122104.bibtex.
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- aggregation isPartOf urn:issn:0032-5791.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in broiler chickens".
- aggregation abstract "Gamithromycin is a new macrolide antibiotic that is only registered for use in cattle to treat respiratory disorders such as bovine respiratory disease. The aim of this study was to determine the pharmacokinetics of gamithromycin in broiler chickens. Gamithromycin (6 mg/kg of BW) was injected intravenously (IV) or subcutaneously (SC) to six 4-wk-old chickens in a parallel study design, and blood was collected at different time points postadministration. Quantification of gamithromycin in plasma was performed using an in-house validated liquid chromatography-tandem mass spectrometry method and the pharmacokinetics analyzed according to a 2-compartmental model. Following IV administration, the mean area under the plasma concentration-time curve (AUC(0 ->infinity)), and a and beta half-life of elimination (t(1/2el alpha) and t(1/2el beta)) were 3,998 h.ng/mL, 0.90 h, and 14.12 h, respectively. Similar values were obtained after a SC bolus injection, i.e., 4,095 h.ng/mL, 0.34 h, and 11.63 h, for AUC(0 ->infinity), t(1/2el alpha), and t(1/2el beta), respectively. The mean maximum plasma concentration (889.46 ng/mL) appeared at 0.13 h. Gamithromycin showed a large volume of distribution after IV as well as SC administration, 27.08 and 20.89 L/kg, respectively, and a total body clearance of 1.61 and 1.77 L/h.kg, respectively. The absolute bioavailability was 102.4%, showing that there is a complete absorption of gamithromycin after a SC bolus injection of 6 mg/kg of BW.".
- aggregation authorList BK1213096.
- aggregation endPage "1522".
- aggregation issue "6".
- aggregation startPage "1516".
- aggregation volume "92".
- aggregation aggregates 4122105.
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- aggregation similarTo ps.2012-02932.
- aggregation similarTo LU-4122104.