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- aggregation classification "A1".
- aggregation creator B505436.
- aggregation creator B505437.
- aggregation creator B505438.
- aggregation creator B505439.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 4123120.bibtex.
- aggregation hasFormat 4123120.csv.
- aggregation hasFormat 4123120.dc.
- aggregation hasFormat 4123120.didl.
- aggregation hasFormat 4123120.doc.
- aggregation hasFormat 4123120.json.
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- aggregation hasFormat 4123120.yaml.
- aggregation isPartOf urn:issn:1465-7392.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Auxin triggers a genetic switch".
- aggregation abstract "Cell specification in development requires robust gene-regulatory responses to transient signals. In plants, the small signalling molecule auxin has been implicated in diverse developmental processes(1,2). Auxin promotes the degradation of AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) inhibitors that prevent AUXIN RESPONSE FACTOR (ARF) transcription factors from regulating their target genes(1,3). However, the precise role of auxin in patterning has remained unclear, the view of auxin acting as a morphogen is controversial(4,5) and the transcriptional control of the ARF genes themselves is barely explored(6). Here, we demonstrate by experimental and computational analyses that the Arabidopsis ARF protein MONOPTEROS (MP) controls its own expression and the expression of its AUX/IAA inhibitor BODENLOS (BDL), with auxin acting as a threshold-specific trigger by promoting the degradation of the inhibitor. Our results suggest a general mechanism for how the transient accumulation of auxin activates self-sustaining or hysteretic feedback systems of interacting auxin-response proteins that, similarly to other genetic switches, result in unequivocal developmental responses.".
- aggregation authorList BK847507.
- aggregation endPage "615".
- aggregation issue "5".
- aggregation startPage "611".
- aggregation volume "13".
- aggregation aggregates 4123131.
- aggregation isDescribedBy 4123120.
- aggregation similarTo ncb2212.
- aggregation similarTo LU-4123120.