Matches in UGent Biblio for { <https://biblio.ugent.be/publication/415812#aggregation> ?p ?o. }
Showing items 1 to 69 of
69
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B183447.
- aggregation creator B183448.
- aggregation creator B183449.
- aggregation creator B183450.
- aggregation creator B183451.
- aggregation creator B183452.
- aggregation creator B183453.
- aggregation creator B183454.
- aggregation creator B183455.
- aggregation creator B183456.
- aggregation creator B183457.
- aggregation creator B183458.
- aggregation creator B183459.
- aggregation creator B183460.
- aggregation creator B183461.
- aggregation creator B183462.
- aggregation creator B183463.
- aggregation creator B183464.
- aggregation creator B183465.
- aggregation creator B183466.
- aggregation creator B183467.
- aggregation creator B183468.
- aggregation creator B183469.
- aggregation creator B183470.
- aggregation creator B183471.
- aggregation creator B183472.
- aggregation creator B183473.
- aggregation creator B183474.
- aggregation creator B183475.
- aggregation creator B183476.
- aggregation creator B183477.
- aggregation creator B183478.
- aggregation creator B183479.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2007".
- aggregation hasFormat 415812.bibtex.
- aggregation hasFormat 415812.csv.
- aggregation hasFormat 415812.dc.
- aggregation hasFormat 415812.didl.
- aggregation hasFormat 415812.doc.
- aggregation hasFormat 415812.json.
- aggregation hasFormat 415812.mets.
- aggregation hasFormat 415812.mods.
- aggregation hasFormat 415812.rdf.
- aggregation hasFormat 415812.ris.
- aggregation hasFormat 415812.txt.
- aggregation hasFormat 415812.xls.
- aggregation hasFormat 415812.yaml.
- aggregation isPartOf urn:issn:0887-6924.
- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCR β-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique".
- aggregation abstract "Recently, we and others described a new chromosomal rearrangement, that is, inv( 7)( p15q34) and t( 7; 7)( p15; q34) involving the T-cell receptor beta ( TCR beta) ( 7q34) and the HOXA gene locus ( 7p15) in 5% of T-cell acute lymphoblastic leukemia ( T-ALL) patients leading to transcriptional activation of especially HOXA10. To further address the clinical, immunophenotypical and molecular genetic findings of this chromosomal aberration, we studied 330 additional T-ALLs. This revealed TCR beta-HOXA rearrangements in five additional patients, which brings the total to 14 cases in 424 patients ( 3.3%). Real-time quantitative PCR analysis for HOXA10 gene expression was performed in 170 T-ALL patients and detected HOXA10 overexpression in 25.2% of cases including all the cases with a TCR beta-HOXA rearrangement ( 8.2%). In contrast, expression of the short HOXA10 transcript, HOXA10b, was almost exclusively found in the TCR beta-HOXA rearranged cases, suggesting a specific role for the HOXA10b short transcript in TCR beta-HOXA-mediated oncogenesis. Other molecular and/or cytogenetic aberrations frequently found in subtypes of T-ALL ( SIL-TAL1, CALM-AF10, HOX11, HOX11L2) were not detected in the TCRb- HOXA rearranged cases except for deletion 9p21 and NOTCH1 activating mutations, which were present in 64 and 67%, respectively. In conclusion, this study defines TCR beta-HOXA rearranged T-ALLs as a distinct cytogenetic subgroup by clinical, immunophenotypical and molecular genetic characteristics.".
- aggregation authorList BK439616.
- aggregation endPage "128".
- aggregation issue "1".
- aggregation startPage "121".
- aggregation volume "21".
- aggregation isDescribedBy 415812.
- aggregation similarTo sj.leu.2404410.
- aggregation similarTo LU-415812.