Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4180562#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B635877.
- aggregation creator B635878.
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- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4180562.bibtex.
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- aggregation isPartOf urn:issn:0161-5505.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "5-HT2A Receptors in the feline brain: 123I-5-I-R91150 kinetics and the influence of ketamine measured with micro-SPECT".
- aggregation abstract "Subanesthetic doses of ketamine can be used as a rapid-acting antidepressant in patients with treatment-resistant depression. Therefore, the brain kinetics of I-123-5-I-R91150 (4-amino-N-[1-[3-(4-fluorophenyl)propyl]-4-methylpiperidin-4-yl]-5-iodo-2-methoxy-benzamide) and the influence of ketamine on the postsynaptic serotonin-2A receptor (5-hydroxytryptamine-2A, or 5-HT2A) status were investigated in cats using micro-SPECT. Methods: This study was conducted on 6 cats using the radioligand I-123-5-I-R91150, a 5-HT2A receptor antagonist, as the imaging probe. Anesthesia was induced and maintained with a continuous-rate infusion of propofol (8.4 +/- 1.2 mg kg(-1) followed by 0.22 mg kg(-1) min(-1)) 75 min after tracer administration, and acquisition of the first image began 15 min after induction of anesthesia. After this first acquisition, propofol (0.22 mg kg(-1) min(-1)) was combined with ketamine (5 mg kg(-1) followed by 0.023 mg kg(-1) min(-1)), and the second acquisition began 15 min later. Semiquantification, with the cerebellum as a reference region, was performed to calculate the 5-HT2A receptor binding indices (parameter for available receptor density) in the frontal and temporal cortices. The binding indices were analyzed with Wilcoxon signed ranks statistics. Results: The addition of ketamine to the propofol continuous-rate infusion resulted in decreased binding indices in the right frontal cortex (1.25 +/- 0.22 vs. 1.45 +/- 0.16; P = 0.028), left frontal cortex (1.34 +/- 0.15 vs. 1.49 +/- 0.10; P = 0.028), right temporal cortex (1.30 +/- 0.17 vs. 1.45 +/- 0.09; P = 0.046), and left temporal cortex (1.41 +/- 0.20 vs. 1.52 +/-. 0.20; P = 0.046). Conclusion: This study showed that cats can be used as an animal model for studying alterations of the 5-HT2A receptor status with I-123-5-I-R91150 micro-SPECT. Furthermore, an interaction between ketamine and the 5-HT2A receptors resulting in decreased binding of I-123-5-I-R91150 in the frontal and temporal cortices was demonstrated. Whether the decreased radioligand binding resulted from a direct competition between ketamine and I-123-5-I-R91150 or from a decreased affinity of the 5-HT2A receptor caused by ketamine remains to be elucidated.".
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- aggregation endPage "1433".
- aggregation issue "8".
- aggregation startPage "1428".
- aggregation volume "54".
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