Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4186862#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B761830.
- aggregation creator B761831.
- aggregation creator B761832.
- aggregation creator B761833.
- aggregation creator B761834.
- aggregation creator person.
- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4186862.bibtex.
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- aggregation hasFormat 4186862.doc.
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- aggregation isPartOf urn:issn:0014-2972.
- aggregation language "eng".
- aggregation publisher "John Wiley and sons".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Role of the renin-angiotensin system on abdominal aortic aneurysms".
- aggregation abstract "BackgroundAbdominal aortic aneurysm (AAA) is a complex degenerative disease, which leads to morbidity and mortality in a large portion of the elderly population. Current treatment options for AAA are quite limited as there is no proven indication for pharmacological therapy and surgery is recommended for AAA larger than 55cm in luminal diameter. Thus, there is a great need to elucidate the underlying pathophysiological cellular and molecular mechanisms to develop effective therapies. In this narrative review, we will discuss recent findings concerning some potential molecular and clinical aspects of the renin-angiotensin system (RAS) in AAA pathophysiology. Materials and methodsThis narrative review is based on the material found on MEDLINE and PubMed up to April 2013. We looked for the terms angiotensin, AT1 receptor, ACE inhibitors' in combination with abdominal aortic aneurysm, pathophysiology, pathways'. ResultsSeveral basic research and clinical studies have recently investigated the role of the RAS in AAA. In particular, the subcutaneous infusion of Angiotensin II has been shown to induce AAA in Apo56 knockout mice. On the other hand, the pharmacological treatments targeting this system have been shown as beneficial in AAA patients. ConclusionsEmerging evidence suggests that RAS may act as a molecular and therapeutic target for treating AAA. However, several issues on the role of RAS and the protective activities of angiotensin-converting enzyme (ACE) inhibitors and Angiotensin 1 receptors blockers against AAA require further clarifications.".
- aggregation authorList BK1129551.
- aggregation endPage "1338".
- aggregation issue "12".
- aggregation startPage "1328".
- aggregation volume "43".
- aggregation aggregates 4186863.
- aggregation isDescribedBy 4186862.
- aggregation similarTo eci.12173.
- aggregation similarTo LU-4186862.