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- aggregation classification "A1".
- aggregation creator B142321.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4191076.bibtex.
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- aggregation isPartOf urn:issn:0735-0414.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Reduced intra-individual reaction time variability during a Go-NoGo task in detoxified alcohol-dependent patients after one right-sided dorsolateral prefrontal HF-rTMS session".
- aggregation abstract "Aims: As alcohol dependency is characterized by severe executive function deficits, we examined the influence of high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) applied to the right dorsolateral prefrontal cortex (DLPFC) on executive functioning in recently detoxified alcohol-dependent patients. Methods: In this randomized, single blind, sham (placebo)controlled, crossover study, we included 50 detoxified alcohol-dependent patients. We examined the effect of a single right DLPFC HF-rTMS session on commission errors, mean reaction times (RTs) and intra-individual reaction time variability (IIRTV) during a Go-NoGo task (50% Go/50% NoGo condition) in 29 alcohol-dependent patients. Patients completed this cognitive task immediately before and immediately after the stimulation session. In order to avoid carry-over effects between stimulation sessions, a 1-week inter-session interval was respected. Because rTMS treatment has been shown to affect subjective craving, all patients were also assessed with the Obsessive Compulsive Drinking Scale (OCDS). Results: After both stimulation conditions, we observed a significant decrease of commission errors, without differences between active and sham HF-rTMS stimulation. No significant difference was observed between active and sham stimulation on mean RT. However, only active stimulation resulted in a significant decrease in IIRTV. No effects of stimulation were found for the craving measurements. Conclusion: Our findings suggest that in recently detoxified alcohol-dependent patients, one right-sided HF-rTMS session stabilizes cognitive performance during executive control tasks, implying that active stimulation reduces patients' proneness to attentional lapses.".
- aggregation authorList BK361527.
- aggregation endPage "557".
- aggregation issue "5".
- aggregation startPage "552".
- aggregation volume "48".
- aggregation aggregates 4392766.
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