Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4191286#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B606538.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
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- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4191286.bibtex.
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- aggregation hasFormat 4191286.dc.
- aggregation hasFormat 4191286.didl.
- aggregation hasFormat 4191286.doc.
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- aggregation isPartOf urn:issn:1757-4676.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF".
- aggregation abstract "Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases. We observed that MMP13(-/-) mice display a strong protection in LPS- and caecal ligation and puncture-induced sepsis. We could attribute this protection to reduced LPS-induced goblet cell depletion, endoplasmic reticulum stress, permeability and tight junction destabilization in the gut of MMP13(-/-) mice compared to MMP13(+/+) mice. Both in vitro and in vivo, we found that MMP13 is able to cleave pro-TNF into bioactive TNF. By LC-MS/MS, we identified three MMP13 cleavage sites, which proves that MMP13 is an alternative TNF sheddase next to the TNF converting enzyme TACE. Similarly, we found that the same mechanism was responsible for the observed protection of the MMP13(-/-) mice in a mouse model of DSS-induced colitis. We identified MMP13 as an important mediator in sepsis and IBD via the shedding of TNF. Hence, we propose MMP13 as a novel drug target for diseases in which damage to the gut is essential.".
- aggregation authorList BK963612.
- aggregation endPage "1016".
- aggregation issue "7".
- aggregation startPage "1000".
- aggregation volume "5".
- aggregation aggregates 4191302.
- aggregation isDescribedBy 4191286.
- aggregation similarTo emmm.201202100.
- aggregation similarTo LU-4191286.