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- aggregation classification "A1".
- aggregation creator B764153.
- aggregation creator B764154.
- aggregation creator B764155.
- aggregation creator B764156.
- aggregation creator B764157.
- aggregation creator person.
- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4207168.bibtex.
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- aggregation isPartOf urn:issn:1759-4790.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "The influence of ageing on the development and management of rheumatoid arthritis".
- aggregation abstract "The population of elderly individuals with rheumatoid arthritis (RA) is expanding, due mainly to increasing life expectancy. A variety of theories have been proposed to explain the ageing process, including accumulation of DNA damage and resultant changes in biological processes. Such changes can influence the development and/or course of disease. Furthermore, alterations in biological function determine the biological age-as opposed to chronological age-of an individual, which strongly influences their ability to cope with disease. Moreover, comorbidities are more frequent in elderly individuals. Together, these factors complicate treatment of disease and necessitate careful patient management. Indeed, although evidence from clinical trials suggests that DMARDs and biologic agents have good efficacy and are well tolerated in elderly patients with RA, such individuals are often undertreated and inadequately managed. Unfortunately, insufficient data are available for the development of evidence-based guidelines for this population, as elderly patients are often excluded from clinical trials owing to age restrictions or comorbidities. Thus, additional clinical studies in elderly patients are warranted, with treatment regimens tailored according to vitality or frailty parameters. This Review focuses on the pathophysiological aspects of ageing and their implications for the management of RA in elderly patients.".
- aggregation authorList BK1133084.
- aggregation endPage "613".
- aggregation issue "10".
- aggregation startPage "604".
- aggregation volume "9".
- aggregation aggregates 4208214.
- aggregation isDescribedBy 4207168.
- aggregation similarTo nrrheum.2013.92.
- aggregation similarTo LU-4207168.