Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4214611#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B382249.
- aggregation creator B382250.
- aggregation creator B382251.
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- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4214611.bibtex.
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- aggregation isPartOf urn:issn:0969-2126.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor".
- aggregation abstract "The discovery that hematopoietic human colony stimulating factor-1 receptor (CSF-1R) can be activated by two distinct cognate cytokines, colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34), created puzzling scenarios for the two possible signaling complexes. We here employ a hybrid structural approach based on small-angle X-ray scattering (SAXS) and negative-stain EM to reveal that bivalent binding of human IL-34 to CSF-1R leads to an extracellular assembly hallmarked by striking similarities to the CSF-1:CSF-1R complex, including homotypic receptor-receptor interactions. Thus, IL-34 and CSF-1 have evolved to exploit the geometric requirements of CSF-1R activation. Our models include N-linked oligomannose glycans derived from a systematic approach resulting in the accurate fitting of glycosylated models to the SAXS data. We further show that the C-terminal region of IL-34 is heavily glycosylated and that it can be proteolytically cleaved from the IL-34:hCSF-1R complex, providing insights into its role in the functional nonredundancy of IL-34 and CSF-1.".
- aggregation authorList BK690703.
- aggregation endPage "539".
- aggregation issue "4".
- aggregation startPage "528".
- aggregation volume "21".
- aggregation aggregates 4238852.
- aggregation isDescribedBy 4214611.
- aggregation similarTo j.str.2013.01.018.
- aggregation similarTo LU-4214611.