Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4238284#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B751670.
- aggregation creator B751671.
- aggregation creator B751672.
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- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4238284.bibtex.
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- aggregation isPartOf urn:issn:2040-2503.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Chemistry".
- aggregation title "Synthesis and antiplasmodial evaluation of aziridine-(iso)quinoline hybrids and their ring-opening products".
- aggregation abstract "Aziridine-(iso)quinoline hybrid systems were prepared as novel synthetic intermediates en route to functionalized (iso)quinolines with potential antimalarial activity. Various quinolinecarboxaldehydes were converted into quinoline-aziridine-pyrazole, -pyridazinone or -pyrimidinone hybrids, and the three-membered azaheterocyclic moiety in these compounds was finally subjected to ring opening by either methanol or water to provide the corresponding functionalized quinolines. In addition, 5-hydroxyisoquinoline was used for the preparation of isoquinoline-aziridine chimeras, which were further transformed into a variety of functionalized isoquinolines via regioselective aziridine ring opening by various nucleophiles. Antiplasmodial evaluation of these new aziridine-(iso)quinoline hybrids and their ring-opening products revealed micromolar potency (0.22-30 mu M) for all representatives against a chloroquine-sensitive strain of the malaria parasite Plasmodium falciparum. The six most potent compounds also showed micromolar activity against a chloroquine-resistant strain of P. falciparum with IC50-values ranging between 1.02 and 17.58 mu M.".
- aggregation authorList BK1118327.
- aggregation endPage "730".
- aggregation issue "4".
- aggregation startPage "724".
- aggregation volume "4".
- aggregation aggregates 4238326.
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