Matches in UGent Biblio for { <https://biblio.ugent.be/publication/428314#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B381041.
- aggregation creator B381042.
- aggregation creator B381043.
- aggregation creator B381044.
- aggregation creator B381045.
- aggregation creator B381046.
- aggregation creator B381047.
- aggregation creator B381048.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2008".
- aggregation format "application/pdf".
- aggregation hasFormat 428314.bibtex.
- aggregation hasFormat 428314.csv.
- aggregation hasFormat 428314.dc.
- aggregation hasFormat 428314.didl.
- aggregation hasFormat 428314.doc.
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- aggregation hasFormat 428314.txt.
- aggregation hasFormat 428314.xls.
- aggregation hasFormat 428314.yaml.
- aggregation isPartOf urn:issn:0012-1797.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways".
- aggregation abstract "OBJECTIVE-Viral infections contribute to the pathogenesis of type 1 diabetes. Viruses, or viral products such as double-stranded RNA (dsRNA), affect pancreatic beta-cell survival and trigger autoimmunity by unknown mechanisms. We presently investigated the mediators and downstream effectors of dsRNA-induced beta-cell death. RESEARCH DESIGN AND METHODS-Primary rat beta-cells and islet cells from wild-type, toll-like receptor (TLR) 3, type I interferon receptor (IFNAR1), or interferon regulatory factor (IRF)-3 knockout mice were exposed to external dsRNA (external polyinosinic-polycytidylic acid [PICex]) or were transfected with dsRNA ([PICin]). RESULTS-TLR3 signaling mediated PICex-induced nuclear factor-kappa B (NF-kappa B) and IRF-3 activation and beta-cell apoptosis. PICin activated NF-kappa B and IRF-3 in a TLR3-independent manner, induced eukaryotic initiation factor 2 alpha phosphorylation and triggered a massive production of interferon (IFN)-beta.This contributed to beta-cell death, as islet cells from IFNAR1(-/-) or IRF 3(-/-) mice were protected against PICin-induced apoptosis. CONCLUSIONS-PICex and PICin trigger beta-cell apoptosis via the TLR-3 pathway or IRF-3 signaling, respectively. Execution of PICin-mediated apoptosis depends on autocrine effects of type".
- aggregation authorList BK688305.
- aggregation endPage "1245".
- aggregation issue "5".
- aggregation startPage "1236".
- aggregation volume "57".
- aggregation aggregates 2936253.
- aggregation isDescribedBy 428314.
- aggregation similarTo db07-0844.
- aggregation similarTo LU-428314.