Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4283483#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B910529.
- aggregation creator B910530.
- aggregation creator B910531.
- aggregation creator B910532.
- aggregation creator B910533.
- aggregation creator B910534.
- aggregation creator person.
- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4283483.bibtex.
- aggregation hasFormat 4283483.csv.
- aggregation hasFormat 4283483.dc.
- aggregation hasFormat 4283483.didl.
- aggregation hasFormat 4283483.doc.
- aggregation hasFormat 4283483.json.
- aggregation hasFormat 4283483.mets.
- aggregation hasFormat 4283483.mods.
- aggregation hasFormat 4283483.rdf.
- aggregation hasFormat 4283483.ris.
- aggregation hasFormat 4283483.txt.
- aggregation hasFormat 4283483.xls.
- aggregation hasFormat 4283483.yaml.
- aggregation isPartOf urn:issn:0950-382X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Carbohydrate-binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei".
- aggregation abstract "The surface of Trypanosoma brucei is covered by a dense coat of glycosylphosphatidylinositol-anchored glycoproteins. The major component is the variant surface glycoprotein (VSG) which is glycosylated by both paucimannose and oligomannose N-glycans. Surface glycans are poorly accessible and killing mediated by peptide lectin-VSG complexes is hindered by active endocytosis. However, contrary to previous observations, here we show that high-affinity carbohydrate binding agents bind to surface glycoproteins and abrogate growth of T.brucei bloodstream forms. Specifically, binding of the mannose-specific Hippeastrum hybrid agglutinin (HHA) resulted in profound perturbations in endocytosis and parasite lysis. Prolonged exposure to HHA led to the loss of triantennary oligomannose structures in surface glycoproteins as a result of genetic rearrangements that abolished expression of the oligosaccharyltransferase TbSTT3B gene and yielded novel chimeric enzymes. Mutant parasites exhibited markedly reduced infectivity thus demonstrating the importance of specific glycosylation patterns in parasite virulence.".
- aggregation authorList BK1290554.
- aggregation endPage "679".
- aggregation issue "4".
- aggregation startPage "665".
- aggregation volume "90".
- aggregation aggregates 4283526.
- aggregation isDescribedBy 4283483.
- aggregation similarTo mmi.12359.
- aggregation similarTo LU-4283483.