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- aggregation classification "A1".
- aggregation creator person.
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- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4283681.bibtex.
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- aggregation isPartOf urn:issn:0007-1048.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Expression of ZAP70 in chronic lymphocytic leukaemia activates NF-κB signalling".
- aggregation abstract "Chronic lymphocytic leukaemia (CLL) is a disease with a highly variable prognosis. The clinical course can however be predicted thanks to prognostic markers. Poor prognosis is associated with expression of a B cell receptor (BCR) from unmutated immunoglobulin variable heavy-chain genes (IGHV) and expression of zeta-associated protein of 70kDa (ZAP70). The reason why ZAP70 expression is associated with poor prognosis and whether the protein has a direct pathogenic function is at present unknown. By transfer of ZAP70 to CLL cells, we show here that expression of ZAP70 in CLL cells leads to increased expression of the nuclear factor (NF)-B target genes interleukin-1 (IL1B), IL6 and IL8 upon BCR triggering. This could be blocked by inhibition of NF-B signalling through inhibition of IB kinases (IKK). Transcriptome analysis identified a NF-B RELA signature imposed by ZAP70 expression in BCR-stimulated CLL cells. We conclude that ZAP70 acts directly as an amplifier of NF-B signalling in CLL cells which could be an underlying mechanism for its association with poor prognosis and which may represent a therapeutic target.".
- aggregation authorList BK887547.
- aggregation endPage "630".
- aggregation issue "5".
- aggregation startPage "621".
- aggregation volume "163".
- aggregation aggregates 4290909.
- aggregation isDescribedBy 4283681.
- aggregation similarTo bjh.12588.
- aggregation similarTo LU-4283681.