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- aggregation classification "A1".
- aggregation creator B832953.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 4301496.bibtex.
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- aggregation isPartOf urn:issn:0931-0509.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Bedside monitoring of anticoagulation in chronic haemodialysis patients treated with tinzaparin".
- aggregation abstract "Background. During haemodialysis, anticoagulants are required to prevent clotting in the extracorporeal circuit. Low-molecular weight heparins (LMWH) are frequently used because of the ease of a single injection at the start of dialysis. Disadvantages of LMWH include the lack of a reliable bedside assay for measuring their anticoagulant effect. Methods. We investigated a bedside test for LMWH activity. The relationship between anti-Xa (chromogenic assay) and Hemonox point-of-care assay was evaluated in 21 dialysis patients (12 men and 9 women) with a median age of 71 years, receiving tinzaparin at the start of a haemodiafiltration session. Results. At the start, before tinzaparin administration, median (interquartile ranges) of Hemonox values were 74 (67–82) s. Thirty minutes after tinzaparin administration, Hemonox values were increased to 496 (360–736) s, followed by a decrease to 149 (135–301) s after 120 min, 102 (97–144) s after 180 min and 92 (83–100) s after 240 min. Corresponding anti-Xa activities were 0 (0–0), 1.12 (0.9–1.29), 0.74 (0.57–0.96), 0.47 (0.31–0.7) and 0.31(0.16–0.49) IU/mL. Hemonox values showed an exponential relation to anti-Xa levels. Interchangeability of tests was shown by Bland–Altman plot. Conclusion. Point-of-care Hemonox test is a valuable bedside method for monitoring anti-Xa activity in dialysis patients anticoagulated with tinzaparin.".
- aggregation authorList BK1207306.
- aggregation endPage "1096".
- aggregation issue "5".
- aggregation startPage "1092".
- aggregation volume "29".
- aggregation aggregates 4301500.
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