Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4305736#aggregation> ?p ?o. }
Showing items 1 to 44 of
44
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B831698.
- aggregation creator B831699.
- aggregation creator B831700.
- aggregation creator B831701.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 4305736.bibtex.
- aggregation hasFormat 4305736.csv.
- aggregation hasFormat 4305736.dc.
- aggregation hasFormat 4305736.didl.
- aggregation hasFormat 4305736.doc.
- aggregation hasFormat 4305736.json.
- aggregation hasFormat 4305736.mets.
- aggregation hasFormat 4305736.mods.
- aggregation hasFormat 4305736.rdf.
- aggregation hasFormat 4305736.ris.
- aggregation hasFormat 4305736.txt.
- aggregation hasFormat 4305736.xls.
- aggregation hasFormat 4305736.yaml.
- aggregation isPartOf urn:issn:2046-2069.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Chemistry".
- aggregation title "Synthesis of 1-substituted epibatidine analogues and their in vitro and in vivo evaluation as α₄β₂ nicotinic acetylcholine receptor ligands".
- aggregation abstract "The highly potent natural alkaloid epibatidine remains a source of inspiration in the search for new analgesic drugs. In this paper, we describe an expansion of our previously reported synthesis of epibatidine analogues, and five synthetic alkaloids characterized by a symmetric, 1-substituted 7-azabicyclo[2.2.1]heptane skeleton, were evaluated for their biological activity. Two of these are binding selectively to the alpha(4)beta(2) subtype of the nicotinic acetylcholine receptor. Their K-i values were determined to be 40 and 290 nM. After a favourable evaluation of these compounds' cytotoxicity and metabolic stability, they were submitted to a rat tail flick test. The compounds did not show antinociceptive effects, which may be caused by a combination of insufficient potency and poor brain penetration.".
- aggregation authorList BK1205329.
- aggregation endPage "2234".
- aggregation issue "5".
- aggregation startPage "2226".
- aggregation volume "4".
- aggregation aggregates 4306746.
- aggregation isDescribedBy 4305736.
- aggregation similarTo c3ra44379e.
- aggregation similarTo LU-4305736.