Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4314428#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B910499.
- aggregation creator B910500.
- aggregation creator B910501.
- aggregation creator B910502.
- aggregation creator B910503.
- aggregation creator B910504.
- aggregation creator B910505.
- aggregation creator B910506.
- aggregation creator B910507.
- aggregation creator person.
- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4314428.bibtex.
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- aggregation hasFormat 4314428.yaml.
- aggregation isPartOf urn:issn:1932-6203.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Artemisinin analogues as potent inhibitors of in vitro hepatitis C virus replication".
- aggregation abstract "We reported previously that Artemisinin (ART), a widely used anti-malarial drug, is an inhibitor of in vitro HCV subgenomic replicon replication. We here demonstrate that ART exerts its antiviral activity also in hepatoma cells infected with full length infectious HCV JFH-1. We identified a number of ART analogues that are up to 10-fold more potent and selective as in vitro inhibitors of HCV replication than ART. The iron donor Hemin only marginally potentiates the anti-HCV activity of ART in HCV-infected cultures. Carbon-centered radicals have been shown to be critical for the anti-malarial activity of ART. We demonstrate that carbon-centered radicals-trapping (the so-called TEMPO) compounds only marginally affect the anti-HCV activity of ART. This provides evidence that carbon-centered radicals are not the main effectors of the anti-HCV activity of the Artemisinin. ART and analogues may possibly exert their anti-HCV activity by the induction of reactive oxygen species (ROS). The combined anti-HCV activity of ART or its analogues with L-N-Acetylcysteine (L-NAC) [a molecule that inhibits ROS generation] was studied. L-NAC significantly reduced the in vitro anti-HCV activity of ART and derivatives. Taken together, the in vitro anti-HCV activity of ART and analogues can, at least in part, be explained by the induction of ROS; carbon-centered radicals may not be important in the anti-HCV effect of these molecules.".
- aggregation authorList BK1290503.
- aggregation issue "12".
- aggregation volume "8".
- aggregation aggregates 4370998.
- aggregation isDescribedBy 4314428.
- aggregation similarTo journal.pone.0081783.
- aggregation similarTo LU-4314428.