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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "1991".
- aggregation format "application/pdf".
- aggregation hasFormat 4325708.bibtex.
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- aggregation isPartOf urn:issn:0378-4347.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "High-performance liquid chromatographic method for the simultaneous determination of R-(−)- and S-(+)-hexobarbital in rat plasma".
- aggregation abstract "The enantiospecific determination of R- and S-hexobarbital in rat plasma is described. The method involves liquid-liquid extraction of racemic hexobarbital from plasma, separation of the underivatized enantiomers by high-performance liquid chromatography on an alpha-1-acid glycoprotein column and ultraviolet detection. The mobile phase consists of a phosphate buffer (pH 5.4) containing 0.4% 2-propanol as organic modifier. An alpha-1-acid glycoprotein guard column is used to increase the lifetime of the analytical column. Heptabarbital is the achiral internal standard. With detection limits of ca. 0.05-mu-g/ml for both R- and S-hexobarbital, the assay is suitable for pharmacokinetic studies of the enantiomers in rats.".
- aggregation authorList BK1205039.
- aggregation endPage "479".
- aggregation issue "2".
- aggregation startPage "472".
- aggregation volume "567".
- aggregation aggregates 4329299.
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- aggregation similarTo 0378-4347(91)80154-5.
- aggregation similarTo LU-4325708.