Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4327685#aggregation> ?p ?o. }
Showing items 1 to 39 of
39
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B873286.
- aggregation creator B873287.
- aggregation creator B873288.
- aggregation creator B873289.
- aggregation creator B873290.
- aggregation creator B873291.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 4327685.bibtex.
- aggregation hasFormat 4327685.csv.
- aggregation hasFormat 4327685.dc.
- aggregation hasFormat 4327685.didl.
- aggregation hasFormat 4327685.doc.
- aggregation hasFormat 4327685.json.
- aggregation hasFormat 4327685.mets.
- aggregation hasFormat 4327685.mods.
- aggregation hasFormat 4327685.rdf.
- aggregation hasFormat 4327685.ris.
- aggregation hasFormat 4327685.txt.
- aggregation hasFormat 4327685.xls.
- aggregation hasFormat 4327685.yaml.
- aggregation isPartOf urn:issn:1751-7362.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Lactobacillus-dominated cervicovaginal microbiota associated with reduced HIV/STI prevalence and genital HIV viral load in African women".
- aggregation abstract "Cervicovaginal microbiota not dominated by lactobacilli may facilitate transmission of HIV and other sexually transmitted infections (STIs), as well as miscarriages, preterm births and sepsis in pregnant women. However, little is known about the exact nature of the microbiological changes that cause these adverse outcomes. In this study, cervical samples of 174 Rwandan female sex workers were analyzed cross-sectionally using a phylogenetic microarray. Furthermore, HIV-1 RNA concentrations were measured in cervicovaginal lavages of 58 HIV-positive women among them. We identified six microbiome clusters, representing a gradient from low semi-quantitative abundance and diversity dominated by Lactobacillus crispatus (cluster R-I, with R denoting ‘Rwanda’) and L. iners (R-II) to intermediate (R-V) and high abundance and diversity (R-III, R-IV and R-VI) dominated by a mixture of anaerobes, including Gardnerella, Atopobium and Prevotella species. Women in cluster R-I were less likely to have HIV (P¼0.03), herpes simplex virus type 2 (HSV-2; Po0.01), and high-risk human papillomavirus (HPV; Po0.01) and had no bacterial STIs (P¼0.15). Statistically significant trends in prevalence of viral STIs were found from low prevalence in cluster R-I, to higher prevalence in clusters R-II and R-V, and highest prevalence in clusters R-III/R-IV/R-VI. Furthermore, only 10% of HIV-positive women in clusters R-I/R-II, compared with 40% in cluster R-V, and 42% in clusters R-III/ R-IV/R-VI had detectable cervicovaginal HIV-1 RNA (Ptrend¼0.03). We conclude that L. crispatusdominated, and to a lesser extent L. iners-dominated, cervicovaginal microbiota are associated with a lower prevalence of HIV/STIs and a lower likelihood of genital HIV-1 RNA shedding.".
- aggregation authorList BK1251993.
- aggregation endPage "1793".
- aggregation issue "9".
- aggregation startPage "1781".
- aggregation volume "8".
- aggregation aggregates 5746617.
- aggregation isDescribedBy 4327685.
- aggregation similarTo ismej.2014.26.
- aggregation similarTo LU-4327685.