Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4328526#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B175644.
- aggregation creator B175645.
- aggregation creator B175646.
- aggregation creator B175647.
- aggregation creator B175648.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 4328526.bibtex.
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- aggregation hasFormat 4328526.doc.
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- aggregation isPartOf urn:issn:1144-0546.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Chemistry".
- aggregation title "One-pot synthesis of superabsorbant hybrid hydrogels based on methacrylamide gelatin and polyacrylamide: effortless control of hydrogel properties through composition design".
- aggregation abstract "BiocompatibLe methacryLamide-modified geLatin (GELMA) hydrogeLs with tuned characteristics, obtained through network-forming photopoLymerization, have recenty attracted increasing attention due to their wide range of possibLe appLications such as drug reLease, tissue regeneration and generation of bioartificiaL impLants. Due to the controlled number of C=C bonds, GELMA may simuLtaneousLy act as macromonomer and crossLinker Leading through poLymerization to hydrogeLs with rationally designed performances. This study provides effortess one-pot synthesis of hybrid hydrogeLs based on covaLenty Linked GELMA and poLyacryLamide (PM), using photo-induced network-forming poLymerization. ConventionaL synthesis of simiLar hydrogeLs Leads to interpenetrating geLatin and PAA networks, usually invoLving muLtistep crossLinking of the components and the use of toxic crossLinkers. Through the described one-pot chemistry, the synthetic water superabsorbent PM with its well-recognized advantages can rationally benefit from the high biocompatibiLity and cell-adherence of GELMA in a simpLe covaLent way. This work provides a correLation between the composition and the corresponding hydrogeL properties (incLuding swelling, pH influence, mechanicaL behaviour, abiLity to generate porous scaffoLds, enzymatic degradation). The addition of PM moduLated the network density and the water affinity allowing the controL of eLasticity and degradabiLity. SuppLementary crossLinking of the synthetic component provided additionaL controL over hydrophiLicity. The capacity of such hydrogeLs to generate porous scaffoLds was proved; interesting morphoLogies were deveLoped onLy by varying the composition. In vitro ceLLuLar studies indicated that the presence of GELMA conferred controlled cell-affinity properties to the bicomponent hydrogeLs. NevertheLess, the drug reLease potentiaL of such hydrogeLs was preLiminarlly investigated using sodium nafcillin. GELMA PM hydrogeLs may be usefuL for tissue regeneration due to effortess synthesis, compositionaL flexibiLity and variabLe properties.".
- aggregation authorList BK429927.
- aggregation endPage "3126".
- aggregation issue "7".
- aggregation startPage "3112".
- aggregation volume "38".
- aggregation aggregates 4328530.
- aggregation isDescribedBy 4328526.
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