Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4328549#aggregation> ?p ?o. }
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- aggregation classification "A1".
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- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 4328549.bibtex.
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- aggregation isPartOf urn:issn:2211-1247.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Tenascin-C downregulates Wnt inhibitor Dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model".
- aggregation abstract "The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-specific matrix, and high TNC expression is linked to poor prognosis in several cancers. To provide a comprehensive understanding of TNC's functions in cancer, we established an immune-competent transgenic mouse model of pancreatic beta-cell carcinogenesis with varying levels of TNC expression and compared stochastic neuroendocrine tumor formation in abundance or absence of TNC. We show that TNC promotes tumor cell survival, the angiogenic switch, more and leaky vessels, carcinoma progression, and lung micrometastasis. TNC downregulates Dickkopf-1 (DKK1) promoter activity through the blocking of actin stress fiber formation, activates Wnt signaling, and induces Wnt target genes in tumor and endothelial cells. Our results implicate DKK1 downregulation as an important mechanism underlying TNC-enhanced tumor progression through the provision of a proangiogenic tumor microenvironment.".
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- aggregation endPage "492".
- aggregation issue "2".
- aggregation startPage "482".
- aggregation volume "5".
- aggregation aggregates 4328750.
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- aggregation similarTo j.celrep.2013.09.014.
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