Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4352552#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B985718.
- aggregation creator B985719.
- aggregation creator B985720.
- aggregation creator B985721.
- aggregation creator B985722.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 4352552.bibtex.
- aggregation hasFormat 4352552.csv.
- aggregation hasFormat 4352552.dc.
- aggregation hasFormat 4352552.didl.
- aggregation hasFormat 4352552.doc.
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- aggregation hasFormat 4352552.yaml.
- aggregation isPartOf urn:issn:1350-9047.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis".
- aggregation abstract "Cytotoxic lymphocyte protease granzyme M (GrM) is a potent inducer of tumor cell death. The apoptotic phenotype and mechanism by which it induces cell death, however, remain poorly understood and controversial. Here, we show that GrM-induced cell death was largely caspase-dependent with various hallmarks of classical apoptosis, coinciding with caspase-independent G2/M cell cycle arrest. Using positional proteomics in human tumor cells, we identified the nuclear enzyme topoisomerase II alpha (topoll alpha) as a physiological substrate of GrM. Cleavage of topoll alpha by GrM at Leu(1280) separated topoll alpha functional domains from the nuclear localization signals, leading to nuclear exit of topoll alpha catalytic activity, thereby rendering it nonfunctional. Similar to the apoptotic phenotype of GrM, topoll alpha depletion in tumor cells led to cell cycle arrest in G2/M, mitochondrial perturbations, caspase activation, and apoptosis. We conclude that cytotoxic lymphocyte protease GrM targets topoll alpha to trigger cell cycle arrest and caspase-dependent apoptosis.".
- aggregation authorList BK1386198.
- aggregation endPage "426".
- aggregation issue "3".
- aggregation startPage "416".
- aggregation volume "21".
- aggregation aggregates 4352573.
- aggregation isDescribedBy 4352552.
- aggregation similarTo cdd.2013.155.
- aggregation similarTo LU-4352552.