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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 4362272.bibtex.
- aggregation hasFormat 4362272.csv.
- aggregation hasFormat 4362272.dc.
- aggregation hasFormat 4362272.didl.
- aggregation hasFormat 4362272.doc.
- aggregation hasFormat 4362272.json.
- aggregation hasFormat 4362272.mets.
- aggregation hasFormat 4362272.mods.
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- aggregation hasFormat 4362272.txt.
- aggregation hasFormat 4362272.xls.
- aggregation hasFormat 4362272.yaml.
- aggregation isPartOf urn:issn:1860-6768.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Shining light on cell death processes: a novel biosensor for necroptosis, a newly described cell death program".
- aggregation abstract "Cell death contributes to the maintenance of homeostasis, but mounting evidence has confirmed the involvement of programmed cell death in some diseases. The concept of programmed cell death, which was coined several decades ago to refer to apoptosis, now also encompasses necroptosis, a newly characterized cell death program. Research on programmed cell death has become essential for the development of some new therapies. To study cell death signaling and its molecular mechanisms, new biochemical and fluorogenic approaches have been devised. Here, we first provide an overview of programmed cell death modes and the importance of dynamic cell death studies. Next, we focus on both apoptotic and necroptotic signaling and their mechanisms by providing a systematic review of all the methods and approaches that have been used. We emphasize the contribution of advanced approaches based on fluorescent probes, reporters, and Forster resonance energy transfer (FRET)-based biosensors for studying programmed cell death. Because apoptosis and necroptosis signaling pathways share some effectors molecules, we discuss how these new tools could be used to discriminate between apoptosis and necroptosis. We also describe how we developed specific FRET-based biosensors for detecting necroptosis. Finally, we touch on how dynamic measurement of biomolecules in living models will play a role in personalized prognosis and therapy.".
- aggregation authorList BK1386351.
- aggregation endPage "240".
- aggregation issue "2".
- aggregation startPage "224".
- aggregation volume "9".
- aggregation aggregates 4362427.
- aggregation isDescribedBy 4362272.
- aggregation similarTo biot.201300200.
- aggregation similarTo LU-4362272.