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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2008".
- aggregation format "application/pdf".
- aggregation hasFormat 436294.bibtex.
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- aggregation hasFormat 436294.yaml.
- aggregation isPartOf urn:issn:1386-6346.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Rapamycin prevents mesenteric neo-angiogenesis and reduces splanchnic blood flow in portal hypertensive mice".
- aggregation abstract "Aim: Increased angiogenesis in the mesenteric microvasculature of portal hypertensive animals may contribute to the development of splanchnic vasodilation associated with portal hypertension (PHT). Experimental data suggest that rapamycin may reduce angiogenesis and tumour growth by inhibiting the vascular endothelial growth factor (VEGF) pathway. This study determines whether rapamycin can prevent the neoangiogenesis in the mesentery of portal hypertensive mice and may influence the splanchnic vasodilation. Methods: PHT was induced by partial portal vein ligation (PPVL). PPVL and Sham mice were treated daily with rapamycin or placebo for 2 weeks. Protein expressions of VEGF, CD 31, Akt and p70S6 kinase (mTOR signalling pathway) were evaluated. Mesenteric blood flow (MBF) was measured by a perivascular flow probe. Results: Increased mesenteric angiogenesis and VEGF protein levels were observed in PPVLplacebo mice compared to Sham(placebo) mice. Rapamycin treatment caused significant reduction in CD 31 positive endothelial cells and VEGF protein in the PPVLrapamycine group compared to the PPVLplacebo group, to levels comparable with Sham(placebo) and Sham(rapamycine) groups. MBF was significantly higher in PPVLplacebo mice compared to the Sham(placebo) mice. Rapamycin decreased significantly the MBF in PPVLrapamycine mice compared to PPVLplacebo mice. Phospo-Akt and p70S6 kinase protein levels were increased in the mesenteric tissue of PPVLplacebo mice compared to Sham(placebo) mice, which were also prevented by treatment with rapamycin. Conclusions: An increased VEGF dependent neo-angiogenesis is present in the mesentery of portal hypertensive mice. Rapamycin prevents angiogenesis in the mesenteric tissue and decreases the mesenteric blood flow in portal hypertensive mice, at least in part through an anti-VEGF activity and influence on the mTOR signalling pathway.".
- aggregation authorList BK496224.
- aggregation endPage "1139".
- aggregation issue "11".
- aggregation startPage "1130".
- aggregation volume "38".
- aggregation aggregates 1041309.
- aggregation isDescribedBy 436294.
- aggregation similarTo j.1872-034X.2008.00369.x.
- aggregation similarTo LU-436294.