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- aggregation classification "A1".
- aggregation creator B838823.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 4381067.bibtex.
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- aggregation isPartOf urn:issn:1465-4644.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Mathematics and Statistics".
- aggregation title "On shrinkage and model extrapolation in the evaluation of clinical center performance".
- aggregation abstract "We consider statistical methods for benchmarking clinical centers based on a dichotomous outcome indicator. Borrowing ideas from the causal inference literature, we aim to reveal how the entire study population would have fared under the current care level of each center. To this end, we evaluate direct standardization based on fixed versus random center effects outcome models that incorporate patient-specific baseline covariates to adjust for differential case-mix. We explore fixed effects (FE) regression with Firth correction and normal mixed effects (ME) regression to maintain convergence in the presence of very small centers. Moreover, we study doubly robust FE regression to avoid outcome model extrapolation. Simulation studies show that shrinkage following standard ME modeling can result in substantial power loss relative to the considered alternatives, especially for small centers. Results are consistent with findings in the analysis of 30-day mortality risk following acute stroke across 90 centers in the Swedish Stroke Register.".
- aggregation authorList BK1214231.
- aggregation endPage "664".
- aggregation issue "4".
- aggregation startPage "651".
- aggregation volume "15".
- aggregation aggregates 4381197.
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- aggregation similarTo kxu019.
- aggregation similarTo LU-4381067.