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- aggregation classification "A1".
- aggregation creator person.
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- aggregation date "2014".
- aggregation hasFormat 4400170.bibtex.
- aggregation hasFormat 4400170.csv.
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- aggregation hasFormat 4400170.doc.
- aggregation hasFormat 4400170.json.
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- aggregation hasFormat 4400170.txt.
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- aggregation hasFormat 4400170.yaml.
- aggregation isPartOf urn:issn:0724-8741.
- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "A model based analysis of IPEC dosing of paclitaxel in rats".
- aggregation abstract "Purpose: A strong pharmacokinetic rational exists for the use of (Hyperthermic) Intraperitoneal Perioperative Chemotherapy in peritoneal carcinomatosis. However, controversy remains regarding the optimal treatment strategies. Paclitaxel is believed to be a good compound for IPEC treatment because of its favourable pharmacokinetic properties. Methods: Rat experiments were set up to gain insight in PTX’s pharmacokinetics and pharmacodynamics after IPEC treatment with Taxol®. Afterwards a Pharmacokinetic—Pharmacodynamic model was developed, that concurrently describes plasma and tumour exposure post IPEC dosing. Moreover, the developed model adequately describes the time-course of tumour apoptosis as well as the treatment effect on tumour volume. Results: We show that the complex absorption processes underlying PTX absorption from the peritoneal cavity post IPEC dosing, give rise to a markedly non-linear dose response relationship. Furthermore, we show that, in order to optimize treatment efficiency whilst concurrently minimizing the possibility of systemic toxicities, lowering the dose and extending exposure to the cytotoxic solution is the way forward. Conclusions: Based on the close resemblance between tumour exposure in our animal model and tumour exposure in patients treated under similar conditions, we hypothesise that, according to our findings in the rat, in the treatment of PC using IPEC administration of PTX, less is truly more.".
- aggregation authorList BK1156944.
- aggregation isDescribedBy 4400170.
- aggregation similarTo s11095-014-1384-5.
- aggregation similarTo LU-4400170.