Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4400201#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
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- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 4400201.bibtex.
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- aggregation hasFormat 4400201.doc.
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- aggregation isPartOf urn:issn:1545-9993.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Structural basis of the proinflammatory signaling complex mediated by TSLP".
- aggregation abstract "Thymic stromal lymphopoietin (TSLP), a cytokine produced by epithelial cells at barrier surfaces, is pivotal for the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis. The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR) and the shared interleukin 7 receptor alpha-chain (IL-7R alpha) to evoke membrane-proximal receptor-receptor contacts poised for intracellular signaling. Binding of TSLP to TSLPR is a mechanistic prerequisite for recruitment of IL-7R alpha to the high-affinity ternary complex, which we propose is coupled to a structural switch in TSLP at the crossroads of the cytokine-receptor interfaces. Functional interrogation of TSLP-receptor interfaces points to putative interaction hotspots that could be exploited for antagonist design. Finally, we derive the structural rationale for the functional duality of IL-7R alpha and establish a consensus for the geometry of ternary complexes mediated by interleukin 2 (IL-2)-family cytokines.".
- aggregation authorList BK1215519.
- aggregation endPage "U115".
- aggregation issue "4".
- aggregation startPage "375".
- aggregation volume "21".
- aggregation aggregates 4400222.
- aggregation isDescribedBy 4400201.
- aggregation similarTo nsmb.2794.
- aggregation similarTo LU-4400201.