Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4410973#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B840571.
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- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 4410973.bibtex.
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- aggregation isPartOf urn:issn:1525-7797.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Spray-dried polyelectrolyte microparticles in oral antigen delivery: stability, biocompatibility and cellular uptake".
- aggregation abstract "During the past decade, extensive research has undeniably improved the formulation and delivery of oral vaccines. Nevertheless, several factors, such as the harsh gastrointestinal environment together with tolerance induction to exogenous antigens, have thus far impeded the optimal effectiveness and clinical application of oral delivery systems. The current study encompasses an initial evaluation of the stability, biocompatibility and cellular uptake of two promising candidate systems for oral antigen delivery, i.e. calcium carbonate- (CP) and mannitol-templated (MP) porous microspheres. Both spray-dried formulations were efficiently internalized by human intestinal epithelial cells (Caco-2 and HT-29) and degraded into phagolysosomal intracellular compartments. In addition, cellular particle uptake and processing significantly up-regulated the expression of (HLA) class-II and costimulatory molecules on intestinal epithelial cells. Even though the high surface-area-to-volume ratio of the microspheres were expected to favor protease access, antigen release was remarkably limited in simulated intestinal fluid and was even absent under gastric conditions. Finally, CP nor MP exerted cytotoxicity upon prolonged in vitro incubation with high antigen concentration. Altogether, these data support the potential of CP and MP for oral antigen delivery and motivate the further development of these promising carrier systems in in vivo studies.".
- aggregation authorList BK1216979.
- aggregation endPage "2309".
- aggregation issue "6".
- aggregation startPage "2301".
- aggregation volume "15".
- aggregation aggregates 4411051.
- aggregation isDescribedBy 4410973.
- aggregation similarTo bm5005367.
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