Matches in UGent Biblio for { <https://biblio.ugent.be/publication/4417315#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B677870.
- aggregation creator B677871.
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- aggregation creator person.
- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 4417315.bibtex.
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- aggregation isPartOf urn:issn:1534-5807.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Germline quality control: eEF2K stands guard to eliminate defective oocytes".
- aggregation abstract "The control of germline quality is critical to reproductive success and survival of a species; however, the mechanisms underlying this process remain unknown. Here, we demonstrate that elongation factor 2 kinase (eEF2K), an evolutionarily conserved regulator of protein synthesis, functions to maintain germline quality and eliminate defective oocytes. We show that disruption of eEF2K in mice reduces ovarian apoptosis and results in the accumulation of aberrant follicles and defective oocytes at advanced reproductive age. Furthermore, the loss of eEF2K in Caenorhabditis elegans results in a reduction of germ cell death and significant decline in oocyte quality and embryonic viability. Examination of the mechanisms by which eEF2K regulates apoptosis shows that eEF2K senses oxidative stress and quickly downregulates short-lived antiapoptotic proteins, XIAP and c-FLIPL by inhibiting global protein synthesis. These results suggest that eEF2K-mediated inhibition of protein synthesis renders cells susceptible to apoptosis and functions to eliminate suboptimal germ cells.".
- aggregation authorList BK1041625.
- aggregation endPage "572".
- aggregation issue "5".
- aggregation startPage "561".
- aggregation volume "28".
- aggregation aggregates 5878749.
- aggregation isDescribedBy 4417315.
- aggregation similarTo j.devcel.2014.01.027.
- aggregation similarTo LU-4417315.