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- aggregation classification "A1".
- aggregation creator B441968.
- aggregation creator B441969.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2008".
- aggregation format "application/pdf".
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- aggregation isPartOf urn:issn:1070-5295.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Is Candida really a threat in the ICU?".
- aggregation abstract "Purpose of review : The epidemiological and clinical relevance of Candida in the ICU is reviewed. Three issues were appraised. First is the prevalence of Candida. Second is the relevance of nonblood cultures positive for Candida and multisite colonization. Third is the importance of invasive candidiasis in terms of mortality. Recent findings : The diagnosis of invasive candidiasis remains problematic in nonblood Cultures. Consequently, the true prevalence of invasive candidiasis is difficult to assess. Another result of the complicated diagnosis is the risk for delayed antifungal therapy in case of systemic Candida infection. Therefore, pre-emptive therapy has become increasingly popular in high-risk patients. Summary : Candida spp. cause a minority of nosocomial bloodstream infections (similar to 4-9%). Yet, delayed initiation of appropriate antifungal therapy results in significant attributable mortality. Given the inability to efficiently discriminate colonization from invasive candidiasis, this is a problematic issue. The presence of Candida in tracheal aspirates, urine cultures or wound swabs frequently reflects colonization. Yet, multisite colonization frequently precedes systemic invasion. As such, multisite Candida colonization is a crucial element in the decision to start pre-emptive therapy. However, the predictive value of multisite colonization in the absence of an overt risk profile for invasive candidiasis appears to be low.".
- aggregation authorList BK771336.
- aggregation endPage "604".
- aggregation issue "5".
- aggregation startPage "600".
- aggregation volume "14".
- aggregation aggregates 4300536.
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