Matches in UGent Biblio for { <https://biblio.ugent.be/publication/515940#aggregation> ?p ?o. }
Showing items 1 to 37 of
37
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B330807.
- aggregation creator B330808.
- aggregation creator B330809.
- aggregation creator B330810.
- aggregation creator B330811.
- aggregation creator B330812.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2008".
- aggregation format "application/pdf".
- aggregation hasFormat 515940.bibtex.
- aggregation hasFormat 515940.csv.
- aggregation hasFormat 515940.dc.
- aggregation hasFormat 515940.didl.
- aggregation hasFormat 515940.doc.
- aggregation hasFormat 515940.json.
- aggregation hasFormat 515940.mets.
- aggregation hasFormat 515940.mods.
- aggregation hasFormat 515940.rdf.
- aggregation hasFormat 515940.ris.
- aggregation hasFormat 515940.txt.
- aggregation hasFormat 515940.xls.
- aggregation hasFormat 515940.yaml.
- aggregation isPartOf urn:issn:1791-2997.
- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Prevention and modulation of aminoglycoside ototoxicity (Review)".
- aggregation abstract "More than 60 years after their isolation and characterization, aminoglycoside (AG) antibiotics remain powerful agents in the treatment of severe gram-negative, enterococcal or mycobacterial infections. However, the clinical use of AGs is hampered by nephrotoxicity and ototoxicity, which often develop as a consequence of prolonged courses of therapy, or of administration of increased doses of these drugs. The discovery of non-ototoxic antibacterial agents, showing a wider spectrum of activity, has gradually decreased the use of AGs as first line antibiotics for many systemic infections. However, AGs are now undergoing an unexpected revival, being increasingly indicated for the treatment of severe emerging infections caused by organisms showing resistance to most first-line agents (e.g., multidrug-resistant tuberculosis, complicated nosocomially-acquired acute urinary tract infections). Increasing adoption of aminoglycosides poses again to scientists and physicians the problem of toxicity directed to the kidneys and to the inner ear. In particular, aminoglycoside-induced deafness can be profound and irreversible, especially in genetically predisposed patients. For this reason, an impressive amount of molecular strategies have been developed in the last decade to counteract the ototoxic effect of aminoglycosides. The present article overviews: i) the molecular mechanisms by which aminoglycosides exert their bactericidal activity, ii) the mechanisms whereby AGs exert their ototoxic activity in genetically-predisposed patients, iii) the drugs and compounds that have so far proven to prevent or modulate AG ototoxicity at the preclinical and/or clinical level, and iv) the dosage regimens that have so far been suggested to decrease the incidence of episodes of AG-induced ototoxicity.".
- aggregation authorList BK623888.
- aggregation endPage "13".
- aggregation issue "1".
- aggregation startPage "3".
- aggregation volume "1".
- aggregation aggregates 517150.
- aggregation isDescribedBy 515940.
- aggregation similarTo LU-515940.