Matches in UGent Biblio for { <https://biblio.ugent.be/publication/515997#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B412099.
- aggregation creator B412100.
- aggregation creator B412101.
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- aggregation creator B412103.
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- aggregation date "2008".
- aggregation format "application/pdf".
- aggregation hasFormat 515997.bibtex.
- aggregation hasFormat 515997.csv.
- aggregation hasFormat 515997.dc.
- aggregation hasFormat 515997.didl.
- aggregation hasFormat 515997.doc.
- aggregation hasFormat 515997.json.
- aggregation hasFormat 515997.mets.
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- aggregation hasFormat 515997.txt.
- aggregation hasFormat 515997.xls.
- aggregation hasFormat 515997.yaml.
- aggregation isPartOf urn:issn:0390-6078.
- aggregation language "eng".
- aggregation title "EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22".
- aggregation abstract "Chromosomal translocations involving the EVI1 locus are a recurrent finding in myeloid leukemia and are associated with poor prognosis. In this study, we performed a detailed molecular characterization of the recurrent translocation t(3;17)(q26;q22) in 13 hematologic malignancies. The EVI1 gene locus was rearranged in all 13 patients and was associated with EVI1 overexpression. In 9 out of 13 patients, the 17q breakpoints clustered in a 250 kb region on band 17q22 encompassing the MSI2 (musashi homologue 2) gene. Expression analyses failed to demonstrate ectopic MSI2 expression or the presence of an MSI2/EVI1 fusion gene. In conclusion, we show for the first time that the t(3;17) is indeed a recurrent chromosomal aberration in myeloid malignancies. In keeping with findings in other recurrent 3q26 rearrangements, overexpression of the EVI1 gene appears to be the major contributor to leukemogenesis in patients with a t(3; 17).".
- aggregation authorList BK730109.
- aggregation endPage "1907".
- aggregation issue "12".
- aggregation startPage "1903".
- aggregation volume "93".
- aggregation aggregates 517127.
- aggregation isDescribedBy 515997.
- aggregation similarTo haematol.13192.
- aggregation similarTo LU-515997.