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- aggregation classification "A1".
- aggregation creator B375430.
- aggregation creator B375431.
- aggregation creator person.
- aggregation date "2008".
- aggregation format "application/pdf".
- aggregation hasFormat 526113.bibtex.
- aggregation hasFormat 526113.csv.
- aggregation hasFormat 526113.dc.
- aggregation hasFormat 526113.didl.
- aggregation hasFormat 526113.doc.
- aggregation hasFormat 526113.json.
- aggregation hasFormat 526113.mets.
- aggregation hasFormat 526113.mods.
- aggregation hasFormat 526113.rdf.
- aggregation hasFormat 526113.ris.
- aggregation hasFormat 526113.txt.
- aggregation hasFormat 526113.xls.
- aggregation hasFormat 526113.yaml.
- aggregation isPartOf urn:issn:0302-2838.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "The schedule and duration of intravesical chemotherapy in patients with non-muscle-invasive bladder cancer: a systematic review of the published results of randomized clinical trials".
- aggregation abstract "Objectives: Intravesical chemotherapy has been studied in randomized clinical trials for >30 yr; however, the optimal schedule and duration of treatment are unknown. The objective is to determine the effect of schedule and duration of intravesical chemotherapy on recurrence in patients with stage Ta T1 bladder cancer. Methods: A systematic review was conducted of the published results of randomized clinical trials that compared intravesical instillations with respect to their number, frequency, timing, duration, dose, or dose intensity. Results: One immediate instillation after transurethral resection (TUR) is recommended in all patients. In low-risk patients, no further treatment is recommended before recurrence. In patients with multiple tumors, one immediate instillation is insufficient treatment. Additional instillations may further reduce the recurrence rate; however, no recommendations can be made concerning their optimal duration. A short intensive schedule of instillations within the first 3-4 mo after an immediate instillation may be as effective as longer-term treatment schedules (grade C). instillations during >= 1 yr in intermediate-risk patients seem advisable only when an immediate instillation has not been given (grade C). Higher drug concentrations and optimization of the drug's concentration in the bladder may provide better results (grade C). Conclusions: The optimal schedule and duration of intravesical chemotherapy after an immediate instillation remain unknown. Future studies should focus on the eradication of residual disease after TUR and the prevention of late recurrences.".
- aggregation authorList BK677982.
- aggregation endPage "719".
- aggregation issue "4".
- aggregation startPage "709".
- aggregation volume "53".
- aggregation aggregates 526734.
- aggregation isDescribedBy 526113.
- aggregation similarTo j.eururo.2008.01.015.
- aggregation similarTo LU-526113.