Matches in UGent Biblio for { <https://biblio.ugent.be/publication/526195#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B223177.
- aggregation creator B223178.
- aggregation creator B223179.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2008".
- aggregation format "application/pdf".
- aggregation hasFormat 526195.bibtex.
- aggregation hasFormat 526195.csv.
- aggregation hasFormat 526195.dc.
- aggregation hasFormat 526195.didl.
- aggregation hasFormat 526195.doc.
- aggregation hasFormat 526195.json.
- aggregation hasFormat 526195.mets.
- aggregation hasFormat 526195.mods.
- aggregation hasFormat 526195.rdf.
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- aggregation hasFormat 526195.txt.
- aggregation hasFormat 526195.xls.
- aggregation hasFormat 526195.yaml.
- aggregation isPartOf urn:issn:0264-410X.
- aggregation language "eng".
- aggregation rights "I don't know the status of the copyright for this publication".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies".
- aggregation abstract "The extracellular domain of influenza A virus matrix protein 2 (M2e) is strongly conserved. Therefore, vaccines based on M2e can induce broad-spectrum immunity against influenza. We have mainly used recombinant virus-like particles derived fromHepatitis B virus core (HBc) as carrier for efficacious presentation of the M2e antigen. Here, we address whether pre-existing HBc-specific immunity interferes with the protective immune response obtained by M2e-HBc vaccination. Anti-HBc antibodieswere induced by immunizing mice with unsubstituted HBc virus-like particles in the presence of two different adjuvants. We demonstrate that pre-existing HBc-specific antibodies affect neither the induction of M2e-specific antibody responses to vaccination with M2e-HBc particles, nor the protective efficacy of the resulting response. These results suggest that vaccination with M2e-HBc can induce protective anti-M2e antibodies even in anti-HBc positive individuals. The implications of these findings are discussed in the context of the clinical development of an M2e-based universal influenza vaccine, which recently successfully completed a Phase I trial.".
- aggregation authorList BK488783.
- aggregation endPage "6507".
- aggregation startPage "6503".
- aggregation volume "26".
- aggregation aggregates 2936500.
- aggregation isDescribedBy 526195.
- aggregation similarTo j.vaccine.2008.09.038.
- aggregation similarTo LU-526195.