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- aggregation classification "A1".
- aggregation creator B161904.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2008".
- aggregation format "application/pdf".
- aggregation hasFormat 530159.bibtex.
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- aggregation isPartOf urn:issn:0891-6640.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Recombinant Human Thyrotropin Administration Enhances Thyroid Uptake of Radioactive Iodine in Hyperthyroid Cats".
- aggregation abstract "Background: Hyperthyroidism is the most diagnosed endocrine disorder in cats and radioiodine (I-131) is the treatment of choice. The dose emission rate and radioactivity in urine, saliva, and on hair and paws are determined by the dose of administered I-131. A dose reduction of therapeutic I-131 could possibly be achieved after recombinant human thyrotropin (rhTSH) administration as in humans with nodular goiter. Hypothesis: rhTSH will increase radioiodine uptake in hyperthyroid cats. Animals: Five hyperthyroid cats. Methods: Twenty-five micrograms rhTSH (day 1) or 2 mL 0.9% sodium chloride (NaCl) (day 9) was injected IV. One hour later, 11.4 +/- 4.1 (mean +/- SD) MBq I-123 was injected IV. Radioactive iodine uptake (RAIU) was measured 6, 12, and 24 hours after rhTSH (RAIU-rhTSH) or NaCl (RAIU-blanco) injection. Blood samples for measurement of TT4 were taken before injection of rhTSH or NaCl (TT4(0)) and at the time of imaging. Results: Percentages of RAIU-rhTSH (and RAIU-blanco) at 6, 12, and 24 hours after administration of rhTSH were 34 +/- 18 (31 +/- 21), 46 +/- 20 (38 +/- 18), and 47 +/- 15 (36 +/- 14). There was a statistically significant effect of rhTSH administration on RAIU (P = .043) but not on serum TT4 concentration. Baseline serum TT4(0) concentration influenced RAIU-rhTSH significantly at 6 hours (P = .037). Conclusion and Clinical Importance: The increased RAIU observed after rhTSH administration in hyperthyroid cats could lead to a lower therapeutic dose of I-131 after rhTSH administration in hyperthyroid cats and decreased risk of environmental and owner contamination during and after hospitalization.".
- aggregation authorList BK401470.
- aggregation endPage "1344".
- aggregation issue "6".
- aggregation startPage "1340".
- aggregation volume "22".
- aggregation aggregates 596283.
- aggregation isDescribedBy 530159.
- aggregation similarTo j.1939-1676.2008.0191.x.
- aggregation similarTo LU-530159.