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- aggregation classification "A1".
- aggregation creator B163047.
- aggregation creator B163048.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
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- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 530495.bibtex.
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- aggregation isPartOf urn:issn:0948-6143.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Human mast cells express leptin and leptin receptors".
- aggregation abstract "Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells. However, there are no data about leptin receptor expression in mast cells. Immunohistochemical and immunofluorescent double stainings showed the expression of leptin and leptin receptors in mast cells in human skin and several parts of the respiratory, gastro-intestinal and urogenital tract. Leptin was expressed in mast cells expressing the classification marker chymase, whereas a variable expression was observed in tryptase positive mast cells. For leptin receptors, the expression pattern was tissue dependent and not related to tryptase or chymase expression. Our results demonstrate the expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells.".
- aggregation authorList BK403832.
- aggregation endPage "711".
- aggregation issue "6".
- aggregation startPage "703".
- aggregation volume "131".
- aggregation aggregates 532637.
- aggregation isDescribedBy 530495.
- aggregation similarTo s00418-009-0575-3.
- aggregation similarTo LU-530495.