Matches in UGent Biblio for { <https://biblio.ugent.be/publication/533109#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B191201.
- aggregation creator B191202.
- aggregation creator B191203.
- aggregation creator B191204.
- aggregation creator B191205.
- aggregation creator B191206.
- aggregation creator B191207.
- aggregation creator B191208.
- aggregation creator person.
- aggregation creator person.
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- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 533109.bibtex.
- aggregation hasFormat 533109.csv.
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- aggregation hasFormat 533109.doc.
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- aggregation hasFormat 533109.xls.
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- aggregation isPartOf urn:issn:0028-646X.
- aggregation language "eng".
- aggregation subject "Biology and Life Sciences".
- aggregation title "C1 metabolism and chlorophyll synthesis: the Mg-protoporphyrin IX methyltransferase activity is dependent on the folate status".
- aggregation abstract "Tetrahydrofolate derivatives are central cofactors of C1 metabolism. Using methotrexate as a specific inhibitor of folate biosynthesis, we altered the folate status in 10-d-old etiolated pea (Pisum sativum) leaves and followed the rate of chlorophyll synthesis upon illumination. In our conditions, the folate concentration decreased only from 5.7 to 4.2 nmol g(-1) FW, but the amount of chlorophyll after 24 h of illumination was reduced 2.5 times. Folate status and rate of chlorophyll synthesis were apparently correlated through the methyl cycle. Indeed, we observed that methyl-tetrahydrofolate was the folate derivative most affected by the treatment; the decrease of methyl-tetrahydrofolate was associated with a sharp rise in homocysteine and S-adenosylhomocysteine concentrations, which are normally maintained at very low values, shifting the methylation index (S-adenosylmethionine/S-adenosylhomocysteine ratio) from 7 to 1; the decrease of the methylation index reduced by a factor of 3 the activity of the Mg-protoporphyrin IX methyltransferase (CHLM), an essential enzyme for chlorophyll synthesis. CHLM gene expression and protein concentration remained unchanged, suggesting that this inhibition relied essentially on metabolic regulation.".
- aggregation authorList BK450508.
- aggregation endPage "145".
- aggregation issue "1".
- aggregation startPage "137".
- aggregation volume "182".
- aggregation aggregates 626504.
- aggregation isDescribedBy 533109.
- aggregation similarTo j.1469-8137.2008.02707.x.
- aggregation similarTo LU-533109.